Role of oxidative stress and inflammatory cytokines in renal injury

Authors

Keywords:

Oxidative stress, Inflammatory cytokines, Renal injury

Abstract

Core tip: Renal injury caused by oxidative stress and inflammatory cytokines is one of the most important causes of chronic renal disease and renal failure. An increase in the level of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6),  and transforming growth factor-beta (TGF-β), and the reduction of the level of these two oxidative stress indexes, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and enhancing malondialdehyde (MDA) expression have shown that inflammatory mediator and oxidative stress are responsible for developing nephropathy by raising the invasion of inflammatory cell, hypertrophy with vacuolar degeneration leading to renal tubular cells apoptosis.

Published

2024-08-10

Issue

Section

Articles