Opisthorchis viverrini-IgG antibody and proinflammatory cytokines IL-1β and TNF-α polymorphisms; synergy factor analysis

Authors

Keywords:

Cholangiocarcinoma, Immunoglobulin, Interleukin, Tumor necrotic factor, Polymorphism, synergy

Abstract

Cholangiocarcinoma is an important biliary tract cancer. This cancer is highly prevalent in Indochina. The opisthorchiasis, the Opisthorchis viverrini infection, is an important etiological factor for cholangiocarcinogenesis.  The measurement of immune response, immunoglobulin G, is a way to monitor the intensity of infection, which can further imply the risk of cholangiocarcinoma. Regarding the disease severity, the role of genetic underlying factors including to proinflammatory cytokines polymorphisms, are mentioned for the important roles. There are some previous case controls studies to assess the odds ratio of the mentioned factors. Nevertheless, in real situation, there are usually complete multifactorial effects of several underlying factors. The synergistic effect due to multifactorial underlying etiologies is very interesting. Here, the authors performed synergy factor analysis for the combined O. viverrini-IgG antibody and to proinflammatory cytokines polymorphisms (IL-1β and TNF-α).

Published

2024-08-10

Issue

Section

Articles