ALOX5AP genetic variants and risk of atherothrombotic stroke; a molecular structure analysis

Abstract

The atherothrombotic stroke is an important thrombohemostatic disorder in clinical practice. The genetic underlying of this thrombohemostatic disorder is widely studied at present. Of several polymorphisms, the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) polymorphism is widely mentioned. The authors conducted a standard molecular structure analysis of 2 important ALOX5AP polymorphisms, rs4293222 and rs4360791. The increased risk of G allele comparing to C allele in rs4293222 and risk of A allele comparing to G allele are equal to 1.36 and 1.76 times, respectively. The increased risk of atherothrombotic stroke is increased in G allele of rs4293222 and the A allele of rs4360791 at different degrees.