Chikungunya virus infection and cholangiocarcinoma; a common pathway network analysis

Abstract

Cholangiocarcinoma is an important endemic malignancy in Southeast Asia. This hepatobiliary cancer is related to the chronic opisthorchiasis. In the same area of Indochina, Chikungunya virus (CHIKV) infection, another mosquito borne infection, is also prevalent. An interesting observation is the null prevalence of concurrent CHIKV infection and cholangiocarcinoma. In this study, the authors used bioinformatics pathway analysis for clarification on this interesting phenomenon. From analysis, no co-occurrence of the two diseases is explainable from the pathway network.