Triple sexually transmitted virus infection, concurrent human immunodeficiency virus, hepatitis B virus and hepatitis C virus infection; analysis on common drug posing drug-drug interaction possibility

Abstract

Sexual contact is an important common activity of human. The medical problem might be due to unsafe sexual contact. An important medical problem due to sexual contact is a sexually transmitted infection. There are several kinds of sexually transmitted infections.  Of several infections, concurrent human immunodeficiency virus, hepatitis B virus and hepatitis C virus infections are the three infections that might be transmitted by sexual contact. These three infections are important public health problems at present. There is a chance that there might be a concurrent infection, a triple infection combining human immunodeficiency virus, hepatitis B virus and hepatitis C virus infection. This combo infection is usually a big problem for management. There is a requirement for several drugs for treatment of each disease in this combo while there is a chance of possible drug-drug interaction. In this study, the authors used pharmacology network analysis to assess the drug-drug interaction among drugs for human immunodeficiency virus, hepatitis B virus and hepatitis C virus infection. The Venn diagram analysis is done then the interrelationship map is constructed. Based on this study, a complex web showing drug-drug interaction in the combo infection can be seen indicating the difficulty in management of this common tropical infection.