Toll like receptor 1 genetic polymorphisms among helicobacter pylori positive and negative Thai patients; a summary report

Abstract

Toll like receptor (TLR) 1 is an important biomolecule that has plays a pivotal role in several medical disorders. In Helicobacter pylori related gastritis, TLR is observed on its clinical interrelationship with gastric dysplasia that is a precancerous condition. Here, the authors summative analyzed the observation of TLR1 polymorphism among Thai patients with H. pylori positive and negative status. According to the analysis, the CC polymorphism is common among the cases with positive H. pylori patients and CT polymorphism is common among negative H. pylori patients. From statistical analysis, no significant relationship between positivity for H. pylori and TLR1 polymorphism was detected (P > 0.05). Based on this observation, TLR1 polymorphism test might not be helpful in monitoring patients with H. pylori infection.