Ischemia and post-injury regeneration in proximal convoluted tubule cells

Abstract

Core tip: Proximal convoluted tubular cells (PCTCs) are multifunctional cells which play significant roles in fluid hemostasis and metabolism. These cells are permanently damaged by exposure to toxic substances. On the other hand, injury could acutely affect them. Therefore, regeneration is a vital process for them. Several studies showed different pathways for their regeneration. But, the most probable way for their generation is the differentiation of scatter tubular cells (STCs) to PCTCs.